PREMPRO/PREMPHASE is an estrogen plus progestin indicated in a woman with a uterus for: Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause (1.1) Treatment of Moderate to Severe Vulvar and Vaginal Atrophy due to Menopause (1.2) Prevention of Postmenopausal Osteoporosis (1.3)

Prempro contains a combination of conjugated estrogens and medroxyprogesterone. Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones.

Medroxyprogesterone is a form of progesterone, a female hormone important for regulating ovulation and menstruation.

Prempro is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.

Prempro should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

Important Information

You should not use Prempro if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will be having major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use Prempro if you are pregnant.

Prempro may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using Prempro can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. Estrogen should not be used to prevent heart disease, stroke, or dementia.